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The persistence of residual neuropathy could increase the risk of cumulative toxicity, and limit the use of carboplatin/paclitaxel in the recurrence setting.
In conclusion, we showed that mucinous ovarian cancer has a poor response to chemotherapy in the recurrence setting along with a worst prognosis.
FISH is not generally used to diagnose primary UC, but is applied as a reflex test for atypical cytology in a monitoring for recurrence setting.
Although pelvic lymph node dissection is considered the most reliable procedure for assessing the presence of nodal invasion in the primary setting, this is often impractical in the recurrence setting [ 2].
Current methods for assessing lymph nodes in the recurrence setting are limited.
Objective response rates to alkylating chemotherapy are low, ranging 5 8% 1, 2. Although bevacizumab has a remarkably high response rate of 25 60% 3, its ability to prolong the overall survival (OS) of patients in the recurrence setting is marginal and it still awaits testing in a randomized clinical trial 4, 5.
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For HZ and PHN-treatment costs we took the lower 95% CI values and neglected recurrence by setting its probability to zero.
"When patients get better and are discharged and have another recurrence, it sets them back to Square 1," said Lynne V. McFarland, an expert at the Puget Sound veterans affairs hospital in Seattle.
Stroke recurrence was set as the end point.
The appropriate cut-off value for the prediction of postoperative recurrence was set at −0.094 with a sensitivity of 88.2% and a specificity of 50.0% by the receiver operating characteristic curve (Suppl. Fig. S5).
The P-value cut-off for indicating the significance of recurrence was set at 0.05 in the study (i.e., a P-value <0.05 indicates the second tumour is likely to be clonally related to the first tumour).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com