Besides the classic parameters related to survival rate and predictor of a poor outcome (e.g. G, T, N, stage and recurrence), a stepwise model introducing P-cad non-expression, without considering recurrence (parameter with the highest OR), showed that also P-cad non expression is significantly associated to survival, together with grading and stage.
Furthermore, 18F-FDG PET/CT has been reported to be effective in predicting head and neck cancer recurrence using quantitative parameters [3].
The aim of this study is to evaluate the impact of lymphocyte infiltration on prognostic parameters, recurrence and survival in ovarian cancer.
These included alternative assumptions concerning time horizon, key cost parameters, recurrence rate, utility value and discount rate.
Thus, when associating ipsilateral local recurrence with other parameters, only the 64 cases that did not receive adjuvant radiotherapy were included.
* Relative risk for recurrence: 2.75 The parameters for incidence translate into an average annualized incidence at age 16 (t = 365 days) of 1.7% for men and 4.0% for women.
Multivariate analyses showed a significant correlation between the rate of loco-regional recurrence and three parameters: EGFR extent superior to 25% (hazard ratio = 7.18, CI 95%, 1.17 46, P = 0.037), rectal resection with microscopic residue (hazard ratio = 6.92, CI 95%, 1.18 40.41, P = 0.032), and a total dose of 44 Gy (hazard ratio = 5.78, CI 95%, 1.04 32.05, P = 0.045).
The association with clinical parameters, recurrence (disease-free survival) and disease-specific survival are provided in Tables 1 and 2, respectively, and correlations between the clinicopathological characteristics of this cohort are shown in Table 3. Sphingosine kinase 1 expression was successfully assessed in all tumours analysed.
These included alternative assumptions concerning time horizon, key cost parameter, recurrence rate, utility value, discount rate and simulation method.
