Sentence examples for recurrence of mutations from inspiring English sources

Screening of 24 additional SMZL for mutations at the same positions found mutated in the WES approach revealed no recurrence of mutations for ZNF608 and PDE10A, whereas the MYD88 L265P missense mutation was identified in 15 % of cases.

Homoplasy is the recurrence of mutations on different branches of the mtDNA phylogeny in different parts of the world.

Recurrence of mutations is actually a predicted characteristic of quasispecies [ 5], thus providing additional support for this interpretation of these data.

Previously used datasets are based on the recurrence of mutations found in the COSMIC database [ 3, 37] or manually curated sets of cancer driver mutations [ 5, 14].

An alternative to single gene tests is to test the recurrence of mutations in groups of genes derived from known pathways [ 7, 8] or genome-scale gene interaction networks [ 9, 10].

The trees reveal insights into three aspects of cancer evolution that are of future clinical relevance: phylogenetic relationships among the pre-invasive lesions and with the IDCs, lineage heterogeneity of pre-invasive lesions, and recurrence of mutations in PIK3CA.

These are the recurrent mutations often with multiple alleles in figure 1 B. The recurrence of the mutations in table 1, even at low abundance, suggests that these are likely to be real population components.

Therefore, we think that the presence of polymorphic mutations in different mutational contexts is more likely due to a high recurrence of punctual mutations than to recombination.

Recurrence of MYD88 mutations in SMZL was validated, but NOTCH2 PEST domain mutations were relatively rare (10%% of cases).

The features that perform reasonably well are based on the recurrence of missense mutations.

On the basis of the trees we were able to show repeated within-patient recurrence of two mutations, H1047R and H1047L, in PIK3CA.