The language of remission and recurrence makes it seem as if the cancer is gone, then back.
Its nature and recurrence make it worth a category by itself.
The aggressive growth pattern and their tendency for recurrence make these tumours difficult to treat.
The combination of unknown aetiology and high rates of recurrence make effective treatment difficult and the outcomes of specific interventions have been shown to be variable [ 7, 8].
However, it needs well-established pedigrees, which is not an easy task in general, and the low rate of MG familial recurrence makes it even more difficult to construct.
CT is known to be more accurate in the detection of hepatic than in the detection of extrahepatic metastases (including local recurrence), making it less ideal for whole-body staging.
Approximately 75 85% of patients present with NMIBC (Parker et al, 1996), and these cancers are associated with a relatively benign course rarely affecting survival, however, surveillance and recurrence makes this an expensive disease to manage.
Ovarian cancer is a particularly relevant model system here because it has such a high rate of recurrence, making the study and understanding of ovarian cancer stem cells potentially quite important.
We examined this paradigm in malignant glioma, a highly aggressive but locoregional primary brain tumor, which is non-metastatic and is characterized by local recurrence, making locoregional therapies of particular relevance.
The need for carefully collected and documented clinical tissue with serial biopsies taken during therapy with defined treatments, TMAs, samples from distant sites and local recurrences made available to investigators is key.
