With the emergence of drug resistance and disease recurrence issues, the current trend of clinical approach is moving towards multi-targeted drugs and combination therapies.
Despite being based on the largest cohort of patients collected from international literature (39.000 overall), this review was based on extremely nonhomogeneous studies, and therefore it did not discuss further important data regarding endoscopic microdiscectomy, such as the rate of complications, recurrence, issues related to indications, and learning curve.
On reviewing clinical records/follow-up, the results of [F]FDG PET/ CT in many circumstances gave information about metastatic disease in locoregional recurrence, resolved issues surrounding equivocal radiology and ensured that patients with second operable cancers were not subjected to major surgery only to succumb to their breast metastasis.
They have standard operating procedures by which they should be able to investigate, evaluate, correct and control to prevent recurrence of the issues we have identified again and again, but they have a lot of difficulty implementing those procedures and, frankly, in having people follow them".
England batsman Trott is playing only his second County Championship match of 2014 and his first since April, having taken a break from the game following a recurrence of anxiety issues which forced him to leave the Ashes tour of Australia last November.
We also assessed macular thickness related to HLA-B27 presence and to recurrence, since these issues have been almost unexplored by previous optical coherence tomography (OCT) studies.
Local complications typically reported after endoprosthetic reconstruction of the proximal tibia include mechanical failure, local recurrence, wound-related issues, and neurovascular compromise (Table 3).
Although surgical shave excision with its myriad modifications has been in vogue for decades, the lack of an adequate histological sample, the largely blind nature of the procedure, and the possibility of recurrence are persisting issues.
Although this issue was beyond the scope of the original study, the volume of data and recurrence of this issue provided a strong rationale for further exploration.
The injury, a recurrence of the issue that led him to miss all of the 2011 season, adds an unhappy final chapter to his time with the Mets.
Meningiomas are usually slow-growing benign tumors, for which complete removal can be difficult and recurrence is an issue.
