Potential risk factors for tumor recurrence identified in this study include attachment sites over the optic nerve and carotid artery or evidence of dysplasia or CIS.
Patient C (Tg-on 2.8 ng/ml) had an extensive paravertebral/mediastinal recurrence, identified on FDG-PET scan, post therapy 131I WBS, and a subsequent MRI, CT scan and octreotide scintigram.
The early, haematogenous pattern of recurrence identified in this study for adenocarcinoma of the oesophago-gastric junction has important clinical implications.
The exclusion criteria for eligibility were receipt of adjuvant radiotherapy or other immunotherapy, concurrent active malignancy, and recurrence identified within 6 months after operation.
All cases were followed-up after the operation (range of follow-up, 9 months to 6 years), with no further recurrences identified in any cases.
This study also did not address the potential for significant lead-time variability between the recurrences identified via imaging or biology and the clinical manifestation of progressive disease.
25 Our subsequent prospective study at the same site documented 109 knowlesi malaria patients successfully treated with A-L, with no recurrences identified.
Thus, the recurrences identified on HR MRI in the central compartment, in the anterior compartment below the peritoneal reflection, in the posterior compartment below S2 or a perineal location are potentially resectable.
In fact, the number of recurrences identified within 1 year after enrollment was lower in the CTHA/CTAP group than the control group (54 vs. 65, data not shown).
In addition, of 1888 local and distant recurrences identified by medical record review among 4455 breast cancer patients assigned to a DBCG protocol, 1813 (96%) were correctly registered as recurrences in the DBCG database, 74 (3.9%) were identified as breast cancer deaths, and only 1 (0.05%) was not identified as either a recurrence or breast cancer death.
