Only faster VT cycle lengths predicted LPFVT recurrence (VT cycle length in patients with and without LPFVT recurrence, 307.7±49.6 versus 361.7±62.7 ms; P=0.03).
Another complete responder (case 2) had tumour recurrence 8 months after last cycle of IA chemotherapy and then he underwent partial penectomy.
138 In fit elderly women aged 70 85 years with HR-negative early BC and a significant risk of recurrence, four cycles of non-pegylated liposomal doxorubicin plus cyclophosphamide was feasible but had a certain impact on social and role functioning; however, autonomy was preserved and toxicity was acceptable.
In each cycle of the model, recurrence risk for each simulated patient is evaluated based on the Recurrence Score category (low, intermediate or high, as reported by Paik et al, 2006; Figure 1).
utility scores used in the model for the recurrence-free state, recurrence state and chemotherapy treatment (6 cycles) were 0.78 (0.60), 0.60 (0.03) and −0.07 (0.01), respectively (Conner-Spady et al, 2005; Milne et al, 2006; Peasgood et al, 2010).
Our results suggest that decreased methylation of this cell cycle regulator is protective against recurrence events.
In contrast to the Onco type DX Breast Cancer Assay, where higher expression of cell cycle genes (STK15, MYBL2, MK167 and CCNB1) is associated with increased risk of recurrence [ 1, 2], higher expression of the colon cell cycle genes (such as CDC20, MCM2, MYBL2, CSE1L, MYC and MK167), was found to correlate with a lower risk of recurrence [ 6].
Do I date remission at the last chemotherapy session, recurrence at the start of the next chemotherapy cycle?
In our model, a series of simulated patients starts each cycle in one of five states: no known recurrence, recurrence curatively treated, recurrence palliatively treated, deceased due to cancer, or deceased due to other causes (See state transition diagram in Figure 2).
Only faster tachycardia cycle length but not the development of new LPF block predicted LPFVT recurrence.
