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Recurrence was identified from histological samples (from biopsy or curative surgery) in all cases except in those with evidence of recurrence consisting of disseminated metastases or those for whom clinical examination, tumour markers and imaging procedures (routinely discussed during a multidisciplinary staff meeting) yielded consistently positive results.
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This recurrence consisted of 2 independent tumors in the same orbit.
Treatment after CNS recurrence consisted of whole brain RT in two patients, surgery (craniotomy) in one patient, and no treatment in two patients.
As there are no data available in the CCCN cancer registry on tumour size and margin status, and because LR had only been registered if the recurrence consisted of invasive disease, it was not possible to evaluate all patients for treatment according to the guidelines.
The secondary endpoint was recurrence-free survival, which was defined as the time from surgery to first evidence of recurrent disease (consisting of local recurrence and distant metastasis) or death from breast cancer.
A subset analysis of 15 groups of recurrent STM MLVA clusters (consisting of 1-2 reachrevealedach) revealedifferenceses in size, duration and spatial density between initial clusters (15 clusters) and corresponding reoccurred clusters (24 clusters) due to the same MLVA type (Table 2).
Cox proportional hazards model was used to test the statistical independence and significance of the different predictors on BCSS (events modeled: deaths attributable to breast cancer only) and RFS (events modeled consisting of recurrences or deaths attributed to breast cancer).
Outcomes were then simulated based on data from landmark trials using a Markov model consisting of four states; no recurrence, recurrence with no metastatic progression, recurrence with metastatic progression, and death.
Post-transplant prophylaxis against reactivation of VZV and herpes simplex virus is recommended to prevent severe recurrences and consists of gancyclovir in patients needing cytomegalovirus (CMV) prophylaxis [ 13].
Forty-two patients with a clinical suspicion of recurrence underwent 1.5-T MRI consisting of standard T2-weighted FSE (3 planes) and an axial DWI (b0,500,1000).
PyRQA is a software package that efficiently conducts recurrence quantification analysis (RQA) on time series consisting of more than one million data points.
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