In these shrublands, fires are frequent, with average recurrence intervals around 10 15 years [ 14].
MR CRM margins >1 mm and <2 mm, >2 and <5 and >5 mm carried a similar risk for local recurrence of around 7%, in contrast to the 20% risk of patients with an anticipated margin of <1 mm [27].
Patients with FIGO stage III G2/G3 with residual disease < 2 cm and FIGO stage II G3 R<2 cm are classified as high risk, with a risk of recurrence of around 80% with a 5-year survival of 25%% [ 14].
Saphner et al. [ 13] reported that compared with ER negative patients, ER positive patients had lower annual hazard of recurrence until around 3.5 years after surgery, but thereafter higher.
A peak in recurrence rates around year 2 for oestrogen receptor-positive breast cancer had been seen in older studies, but this is very much diminished in more recent studies, where now the recurrence rate is roughly constant for at least 10 years.
Recent case series suggest that after laparoscopic radiofrequency ablation for NET liver metastases, local recurrence is around 6% and symptomatic relief is achieved in 70 95% of patients, with a 5-year survival of 57% and a median survival of 3.9 years after the first radiofrequency ablation.
It is the most prominent risk factor for suicide [ 3] and its high prevalence coupled with negative effects on function and the likelihood of recurrence for around half of those affected mean it is currently the third leading cause of disease burden in the world, and the leading cause in middle- and high-income countries [ 4].
Recurrences are around 3%.
Following primary resection, most patients with pTa or pT1 tumours will develop recurrences, while around 10 20% will suffer progression to potentially life-threatening muscle-invasive disease.
More than 60% of these patients experience bladder tumour recurrences and around 20% of the patients develop disease progression to a muscle-invasive bladder cancer (Millan-Rodriguez et al, 2000; Sylvester et al, 2006).
