If we compare our results to findings of two high quality randomised controlled studies performed in secondary care by Dammers et al. and Armstrong et al. it appears that response rate in our study is less (50% compared to 70% in study by Dammers and 70% in the study by Armstrong), but duration of treatment response, recurrence rates and timing of recurrences were similar[ 14, 15].
The frequency of imaging should be adjusted according to the risk of recurrence and the timing and conditions of treatment [ 52].
Surgical resection of primary tumour removal may either 'cure' a significant fraction of patients, or it may even change the 'natural' recurrence and death timing for some others, by accelerating the metastatic development [ 7, 8].
Clinical and experimental validation of model predictions of relapsed tumor composition over time and recurrence timing are important for correct calibration and refinement of our model.
Ancillary outcomes included length of disease-free period after the first and additional courses of intralesional therapy, time to outcome, number and timing of recurrences and adverse effects.
The purpose of this study was to clarify the pattern and timing of recurrence after extended radical esophagectomy.
Because of the clinical similarities of TNB and SQCC with respect to rate and timing of recurrence in early stage cases, we also applied our logistic regression approach to a TNB subset of their data set.
Because of selection bias, studies of patients with metastatic disease are not ideal for examining sites and timing of recurrence associated with HR status in HER-2-positive disease overall.
The intensity, timing, recurrence, and type of disturbance can affect the rate of crust recovery even up to 30 years post disturbance (Bowker et al. 2004; Ford and Johnson 2006; Lalley and Viles 2008; Marble and Harper 1989; Zaady et al. 2007).
Secondary outcomes (at 24 months) were: investigations, number and timing of recurrences and deaths.
