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Tamoxifen, which blocks the effects of estrogen, significantly reduces the recurrence and spread of estrogen-sensitive cancers, which are the most prevalent.
In March 2007, the couple announced the recurrence and spread of her disease — and their intention to continue campaigning.
But medical experts were quick to question the significance and methodology of the study, saying clinical trials had repeatedly found that the drug, tamoxifen, reduced the recurrence and spread of common breast cancers and that its benefits exceeded any possible risks.
The researchers said that the drugs also were found to take aim at a small but dangerous subpopulation of self-renewing cells, sometimes referred to as cancer stem cells, which evade most cancer drugs and cause recurrence and spread.
It is likely that this is a common contributor to the recurrence and spread of the disease.
Fascin expression contributes to progression of human PDAC, but is only of borderline significance as a prognostic indicator, indicating that other factors contribute to recurrence and spread.
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Despite initial local control (achieved by surgery with or without radiation), local recurrence and systemic spread commonly occur and the lack of effective therapeutic options in these clinical scenarios is the major unresolved problem in STS.
Tumour recurrence and metastatic spread can be monitored in vivo.
Cancer stem cells (CSCs) are proposed to be responsible for chemotherapeutic treatment failure, disease recurrence and metastatic spread.
If rhIL2 has local or systemic effects, it should decrease the rates of recurrence and distant spread.
It has been postulated that the CSC component of tumours contributes to decreased efficacy of chemotherapy, and may ultimately be responsible for tumour recurrence and metastatic spread.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com