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Local recurrence and occurrence of distant metastases were not registered by the cancer registry.
These studies have provided strong evidence for a large preventive effect of folic acid on both recurrence and occurrence of NTDs.
The NTD research provides a model for developing clinical trials aimed at assessing preventive effects of folic acid on recurrence and occurrence of oral clefts of direct relevance for clinical practice.
These results strongly indicate that the preventive effects on recurrence and occurrence of NTDs are due to the folic acid component rather than the other vitamins, though interactive effects have not been thoroughly evaluated.
This study describes the application of CCA to find important predictors for two different outcomes for breast cancer patients, loco-regional recurrence and occurrence of distant metastasis and to decrease the number of variables in the sets of predictors and outcomes without decreasing the predictive strength of the model.
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Local recurrence and metastasis occurrence in our study were in accordance with randomised trials (Minsky et al, 1999; Seitz et al, 2000; Bedenne et al, 2007).
Information of covariate data was available for the patients, and included age at operation, gender, TNM-stage, tumour location, tumour diameter, microsatellite stability status (MSS-status), history of cancer, adjuvant treatment, tumour recurrence, and the occurrence of a new primary tumour in the follow-up period.
Tumor grade, stage, metastasis, and occurrence of recurrence were available for prediction [ 30, 31].
No difference was found between the levels of Tregs and HPV status (P = 0.929), tumor size (P = 0.780), tumor grade (P = 0.116), and nodal status (P = 0.253), and occurrence of recurrence (P = 0.251) was found (data not shown).
In several studies smoking is strongly related to LTUC and possibly UTUC in occurrence, recurrence, and progression [ 8, 12, 16].
However, their relation to occurrence, recurrence and death of bleeding in the population level is not clear.
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