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In the case of dynamic-clamp conductance injection we found that the I V curve was best fitted by a non-linear integrate-and-fire model that comprised two exponential components: the sharp exponential activation associated with the spike-generating sodium current is preceded by a slow inward rectification that is also very close to exponential.
It was assumed that g o and g c values exhibit rectification, that is, depend on Vleft/right exponentially: (21) g o V left right, P = 2 · exp P · V left right R o, g c V left right, P = 0.25 · exp P · V left right R c, where Vleft/right is a voltage across the left or right hemichannel, while R o and R c are rectification constants.
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One of the key factors contributing to the sudden surge is the national P2P rectification campaign that was supposed to have been finished by June.
Current rectification is reversible in quartz nanopipets that are modified by immersing the pipet in a saccharide-binding polymer.
For example, direct measurements of glutamate release (imaging of iGluSnFR) in ON layers, revealed that rectification is mild, and that a temporal nonlinearity (transient increases in release) explained nonlinear behavior in postsynaptic ganglion cells (Borghuis et al., 2013).
These data provide the most definitive evidence to date that rectification is achieved by differential regulation of the pre- and postsynaptic elements of structurally asymmetric junctions.
Run-up of current likely results from the process of calcium diffusing from the pipette solution into the cell, suggesting that rectification is also calcium-dependent, as has been shown for CaCCs (Yang et al., 2008).
It seemed that rectification was attributed to both charge and steric effects at low concentration.
Further analysis reveals that the rectification is governed by the monotonic evolution of the strongly localized frontier molecular orbitals under external bias voltages.
It is known that the rectification is of great importance in modern electronic applications [24].
It suggested that the rectification is attributed to both charge and steric effects at low concentration, while the steric effect is dominant at high concentration.
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