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The primary tumour was of colonic origin in 67.0% of patients and of rectal origin in 29.8% of patients.
In all, 52% of tumours were of colonic origin and 39% were of rectal origin, and in 9% of cases the site was not recorded.
3 patients had a metastatic adenocarcinoma to the vagina (1.6%), 1 being of rectal origin, 1 of ovarian and 1 of endometrial origin.
Another limitation is that we included in this analysis different location of primary tumor, even if only metastasis of the rectal origin demonstrated differences and colonic metastases are analyzed separately.
PDGFR B19 SNP has been reported to be present in the general population with a frequency of 37%, and was more commonly encountered in our study population among colon primary tumors (64%) than in tumors of rectal origin (35%).
When looking at the subpopulation of colorectal cancer metastases, size >2 cm (HR = 1.34, P = 0.054), number of metastases ≥3 (HR = 1.70, P = 0.0005), rectal origin (HR = 1.24, P = 0.12) and extrapulmonary disease (HR = 1.28, P = 0.11) remained significantly or borderline significantly associated with PFS.
Similar(53)
We first examined whether GPS expression differs between tumours of rectal and colonic origin.
Suppressed expression of TMEFF2 is associated with its hypermethylation in several human tumor types, including glioblastoma and cancers of ovarian, rectal, colon and lung origins.
Nevertheless, taken together with other published reports of TMEFF2 methylation in other tumor types, these data are consistent with the hypothesis that TMEFF2 is silenced through DNA methylation in a significant proportion of human cancers, including glioma and cancers of ovarian, rectal, colon and lung origins.
In this study, rectal swabs from cats of different origin (house cats, group-housed cats, diseased cats) were cultured for Salmonella.
8 For rectal cancer this is at the origin of SRA (low tie), which is immediately distal to the offspring of LCA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com