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Most RECs review the research that is conducted at their own institutions.
Since the HRA incorporates the National Research Ethics Service NRESS), whose research ethics committees (RECs) review and provide ethical opinions on all research using NHS patients, it seemed logical that the HRA plays a greater role in monitoring publication outcomes.
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Of those who responded (n = 9), RECs reviewed an average of 3.8 protocols per meeting (median: 2.5, range 1 - 10) and an average of 42.3 protocols per year (median: 22; range 1-150).
However, by still relying on comprehensive ethics review at each project site in each country, the potential for global bottlenecks and incongruence remain, with multiple RECs reviewing a research project that seeks to aggregate and use data on a global scale.
The shortcomings of protocols that are identified during REC review have not been compared by sponsor type though.
In Table 3, random examples of comments raised during REC review are presented to illustrate each type of shortcoming.
However, several studies on REC review included small numbers of protocols [ 5, 9, 10], or focused on protocols submitted to single RECs so resulting findings may be specific to the committee studied [ 5, 6].
To maintain or, in many cases, to restore public and professional trust in the ethics of human research and in REC review of protocols, it is imperative that steps be taken to clarify the accountability of RECs and their individual members.
In Leiden and Amsterdam, protocols are reviewed by science committees before submission to the REC, which may reduce the time needed by RECs to review methodological aspects.
To identify prognostic indicators of the publication rate of clinical studies, available to research ethics committees (RECs) during review.
Level 2 RECs may review all types of health research.
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