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Finally, 234 perinatal women were recruited in the original study with a recruitment fraction of 92%.
With a conservatively estimated 50% recruitment fraction, the required number of participants will be able to be recruited from 48 MCH centres (clusters), which each provide care to at least 16 primiparous women per annum (figure 1).
Recruitment occurred via consecutive sampling and the recruitment fraction was 80% (Kinner et al. 2014).
The recruitment fraction could be calculated for 103 trials (70%), with a median participant recruitment of 41% (IQR 16%to7171%) (Table 3).
Of the 646 eligible couples invited to participate, 399 women completed the first interview giving an overall recruitment fraction of 61.8%.
Main outcomes were: (1) eligibility fraction (proportion eligible of those screened), (2) enrolment fraction (proportion randomised of those eligible), (3) recruitment fraction (proportion of potential participants actually randomised), and (4) number of patients needed to be screened (NNS) in order to randomize one participant.
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Researchers can make more realistic estimates of the resources required if the likely eligibility and recruitment fractions are known to be low.
Eligibility, enrolment and recruitment fractions were calculated in the same way as Gross et al.[ 12] We summarized RCT characteristics as proportions and compared groups using the chi-squared test.
Consequently, the reported median eligibility (65), enrolment (93) and recruitment (54) fractions in this study should be treated with some caution (Table 3).
The pathway to sample selection, and recruitment and retention fractions for the cohort from which this sub-sample was drawn, are summarised in Figure 1.
Our finding that anti-Asl antibodies strongly block the recruitment of the mobile fraction of Asl to mother centrosomes also supports this possibility.
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