Comparing the magnitude of the changes in mRNA abundance to direct measurements of the efficiency with which each mRNA is recruited to RISC revealed a quantitative relationship between the recruitment efficiency and consequences for expression.
The ACCORD vanguard phase, conducted at 59 clinics in the United States and Canada, recruited 1,174 participants in 20 weeks from January through June 1 , 2001 with a recruitment efficiency (R-factor) of 0.65.
It is concluded that discharge from sensory receptors signalling shoulder position may act to regulate the gain of the excitatory drive-firing rate relation of motoneurones in order to compensate for reduced recruitment efficiency.
Although new and refined recruitment strategies were formulated from the vanguard experience, the most powerful determinant of improved recruitment efficiency was the immediate start of enrollment by most clinics at the beginning of the main trial.
Evidence exists that shoulder joint geometry influences recruitment efficiency and force-generating capacity of hand muscles [Ginanneschi, F., Del Santo, F., Dominici, F., Gelli, F., Mazzocchio, R., Rossi, A., 2005.
Moreover, the link between size, number of seed matches and recruitment efficiency suggests an evolutionary mechanism for quantitative tuning of the regulatory response of each mRNA to a miRNA.
This index can be calculated using retrospective data and may be a useful tool for comparing recruitment efficiencies among various resources.
These widespread patterns are also observed when the mechanisms for diffusion and recruitment are combined together even at low recruitment efficiencies.
Such differences may account in part for the discordant results seen in Phase II and Phase III trials and raise important questions regarding the external validity of conclusions from trials with low inclusion or recruitment efficiencies.
In the recruitment mechanism, we considered a relatively low recruitment-efficiency (RE) of 0.5.
Additionally, the modification induced recruitment mechanism with a low recruitment-efficiency gives rise to patterns that are similar to patterns generated by the diffusion mechanism.
