The phosphorylation events instead allow subsequent recruitment and binding of transcriptional co-activators CREB binding protein (CBP /p300 as well as transducers of regulated CREB (TORCs) to the promoter region [ 32- 35].
In addition to regulating interactions through recruitment of binding domains, PTMs can also tune the binding affinity of protein interactions by changing the properties of interfaces between globular domains.
Although the catalytic function of the exosome core has been lost during evolution, the substrate recruitment and binding properties have been conserved from prokaryotes to eukaryotes.
While we could determine significant effects of PTX3 presence in MSCs in 1 week to modulate fibrosis, the downstream effects of PTX3 presence in MSCs during the early acute phase (e.g., modulation of leukocyte recruitment by binding with P-selectin) remains to be elucidated.
In contrast, there is relatively little knowledge about the dynamics of ICAM-1 recruitment upon binding to an adhered leukocyte.
The PH domains of AKT and PDK1 mediate membrane recruitment through binding to phosphatidylinositol lipids [6], [19].
Though much remains unknown about ribosome recruitment and binding in archaea, using a species-specific RBS should enhance the accuracy of start codon identification.
SH3 domains contribute not only to SFK regulation (see Introduction) but also to substrate recruitment by binding to target proteins containing polyproline type II helices [23].
Histone modifications can also prevent the recruitment of binding proteins.
