Fourth, we recruited a broad range of participants, with regard to severity of depression (a minimum of 8 and a maximum of 44 on BDI-II at intake).
The trial is eligible for UK National Institute for Health Research Clinical Research Network support, allowing us to work with the Primary Care Research Networks (PCRN, South-Central, East and North Hubs) in recruiting a broad range of practices to take part in the trial.
Recruiting patients from a broad range of settings yields a representative sample, and simultaneously patient recruitment times can be reduced [ 1, 2].
Recruited participants represented a broad range of income and education levels, reflecting background Australian population levels as we have reported previously.
Respondents were recruited to ensure that a broad range of experiences and perceptions were identified; including women who had lived in Australia for varying lengths of time, and with a varying number of children.
Recent studies have provided direct evidence that MSCs are recruited in TME by a broad range of soluble factors which are secreted by cancer cells and CSCs, including IL-6 [ 179], VEGF and bFGF [ 180], CCL2 [ 181], SDF-1 α [ 182], and HMGB1 [ 183].
Often chronic patients or inpatients have been recruited; such cohorts have experienced a broad range of primary stressors prior to illness as well as secondary stressors associated with the illness (e.g., acute illness phases, relapses and medication).
To ensure the representativeness of this sample, we employed a diverse range of purposive, theoretical and strategic sampling methods [ 29, 30] to recruit participants who were representative of a broad range of socio-cultural, demographic, geographic and weight groups within the obesity range, allowing us to explore the findings in the context of socio-cultural risk communication literature.
More recently, neuroimaging research has demonstrated that a network distributed across the frontal and parietal lobes is commonly recruited when difficulty is increased across a broad range of task contexts (Duncan and Owen 2000; Nyberg et al. 2003; Dosenbach et al. 2006; Duncan 2006).
