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Particular attention is given to mechanisms that cause cell death and organ dysfunction and to prospective therapeutic strategies, directed to recover mitochondrial function.
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We further showed that overexpression of inactive GAPDH rescues this inhibited process of micro-mitophagy, recovering mitochondrial functions and promoting cell survival.
Moreover, its sensitiveness to CCCP was recovered, indicating the integrity of the mitochondrial function (not shown).
Cell treatment with SB203580 was sufficient to recover partially senescence phenotype, to block the ROS elevation, to decrease the mitochondrial function, and finally to rescue proliferation.
A comparison of gene expression profiles early and late following EBV infection revealed that those who did not recover had differentially expressed genes implicating mitochondrial perturbations with fatty acid metabolism, mitochondrial function and apoptosis pathways.
Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.
Mitochondrial fusion is essential for maintenance of mitochondrial function.
MIBI retention may depend on mitochondrial function.
This review summarizes our current knowledge on mitochondrial architecture, mitochondrial protein import, and mitochondrial function.
Hence, it exhibited protective effects on mitochondrial function without reducing mitochondrial O2 consumption.
Thus, the intermembrane mitochondrial CuZn-SOD would probably contribute to the HMF-inhibited mitochondrial function.
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