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Medical records verification forms were received for 70.4% of those requested, and 10.2% of all case reports received.
For the selected cases, neurologists were asked to complete a more detailed medical records verification form and submit a recent electromyogram (EMG) to ensure diagnostic accuracy.
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This self reporting often led to data collection on non-specific forms that did not include a question prompting the investigator to record verification of diagnosis details.
A medical record verification form and an electromyogram (EMG) report were requested for a sample of cases and reviewed by an independent consulting neurologist to confirm ALS diagnosis.
Future studies on surgical complications should endeavour to use both data sources and include primary care record verification of unconfirmed patient-reported Grade II complications.
To ensure accuracy of case diagnosis, a symptom-oriented Medical Record Verification Form (MRVF) and electromyogram (EMG) report were requested on a sample of reported cases.
In an effort to accurately and objectively report CRC screening rates in this population, we also validated self-reports of CRC screening with medical record verification in a sample subgroup.
Our duration imputation validation performed by the use case and comparisons of quantity/numeric daily dose and the duration imputation had acceptable results, but because 26%% of CPRD source drug exposures have no daily dose information, we believe source record verification would need to be evaluated to create a best practice for inference.
In addition, we were not able to conduct source record verification to assess the validity of the assumptions or to gauge whether one data source's original data structure is more or less reliable than another in their ability to properly classify inpatient encounters.
Results were manually cross-checked against Statistics Canada records for verification.
The data were not linked to any medical records for verification.
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