At this aim, we propose the combined use of visual evoked potential (VEP) recordings and BOLD-fMRI measurements prior to SE MRI scanning.
Several studies using simultaneous EEG fMRI have investigated single-trial correlations between the amplitude and/or latency of ERPs, derived from scalp EEG recordings, and the BOLD signal [Benar et al., 2007; Debener et al., 2005; Eichele et al., 2005; Fuglo et al., 2012; Mulert et al., 2008].
On the other hand, in VEP and VEF recordings, in contrast to BOLD recordings, V1 activity under the full-field stimulation was problematic because the field activities of neurons in the upper and lower banks of the calcarine fissure canceled each other out.
BOLD-fMRI recordings were performed at baseline, T5min, T15min, T25min, T35min, T45min, T55min and T65min.
Intracortical electrophysiological recordings showed a similar trend as the BOLD but the neurovascular coupling varied.
For example, it has been found that in the visual cortex of macaque monkeys intracranial recordings of LFP correlated positively with the BOLD in the gamma range [77].
Electrophysiology recordings of multi-unit activity corroborated the BOLD observations: visually driven multi-unit responses could be elicited inside the V2 LPZ, even when the visual stimulus was entirely contained within the scotoma induced by the V1 lesion.
Most multimodal studies mapping haemodynamic changes related to specific electrophysiological phenomena use scalp EEG, whereas those focused on characterising the local relationship between the electrophysiology and BOLD often involve invasive electrophysiological recordings.
Shmuel and colleagues [23] demonstrated that negative BOLD is correlated with decreased neuronal activity by simultaneously measuring electrical recordings and fMRI activity of visual cortex.
They're bold, remixing classics from Prince and playing with boundaries on their own recordings.
