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Mean area, medio-lateral and antero-posterior CoP path lengths were calculated for each subject and condition, considering the last 9 seconds of each recording trial, as in the main experiment (see Methods).
Each recording trial consisted of 2 s of complete darkness followed by a 10 ms flash (to monitor sensitivity).
MPEP or vehicle (0.9% NaCl) was given 30 min prior to the next recording trial to ensure adequate time for the drug to reach the brain and to observe for any effect of the injection procedure.
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All individual voice and brain recording trials were manually inspected and discarded if artifacts were noted.
Single-unit recording trials took place in one of two recording arenas.
Two or more head direction cells were recorded simultaneously in nine pairs of recording trials (22 cells, 20 cell pairs).
Circular correlations between cell pairs were calculated for each of the two recording trials with at least three simultaneously recorded cells.
The agency's initial review of the Record trial, in 2007, found no problems.
The company's conduct of the Record trial has received sharp criticism from medical leaders for other reasons as well.
However, since the Record trial is the only randomized clinical trial to directly evaluate the cardiovascular risks of Avandia, others have said its results should be taken seriously.
In that 2007 advisory meeting, the Record trial -- specifically devised to assess Avandia's heart risks -- was a significant source of reassurance for Avandia's supporters.
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