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GENRE and GEM limitations suggest opportunities for future efforts to improve computational reconstruction of established biochemistry and can highlight portions of metabolism that are ripe for further research [ 37].
In such cases, expanding the reconstruction of established knowledge would not be expected to improve a model's ability to predict single-gene mutant viability, and so such metrics would not reflect the expanded scope of the reconstruction.
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The authors present their experience of elective reconstructions of established deformities in the extremities for aesthetic purposes using free perforator flaps.
This update improves the consensus reconstruction's coverage of established biochemical knowledge, and improves the predictive ability of simulations using the yeast GEM.
Thus, a metabolic model based upon a reconstruction with improved coverage of established biochemistry of isoenzymes would make less accurate predictions of individual gene essentiality than a model based upon a less complete reconstruction.
Specifically, nonlinear forecasting comprises a set of established methods from nonlinear time series analysis that involve state space reconstruction with lagged coordinate embeddings [51], [52].
This type of 3-D reconstruction clearly established that microglial fragmentation (cytorrhexis) was not due to selective focusing but instead represented the actual morphology of both clustered and surrounding cells.
Data from flight recorders and reconstruction of the wreckage established that the blast had taken place in baggage container 7044 RK.
The nearby scenic coastal area is part of Sanriku Fukko (Sanriku Reconstruction) National Park (established 2013), which incorporates the former Rikuchū-kaigan National Park and stretches northward along the Pacific.
A special calcium phosphate resin, which was designed for the gradual release of large amounts of these elements in places that require reconstruction, was established very quickly.
This study prepared a uterine auto-transplantation model in cynomolgus monkeys, with the goal of establishing a fecundity reconstruction technique.
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