Sentence examples for reconstitution potential from inspiring English sources

Therefore, clonal mMSCs were evaluated for their reconstitution potential.

The CD34− compartment of the Sca-1lo cells contained virtually all expression of the erythroid TF Gata1 and had accelerated erythroid differentiation but no culture reconstitution potential, while CD34+ cells were multipotent.

Primed HSCs provide ongoing support for the daily normal regeneration of billions of blood cells, whereas dormant HSCs that have maximal, long-term reconstitution potential are mobilised upon bone marrow injury (Wilson et al., 2008; Trumpp et al., 2010).

However, cells from the basal layer have the most robust long-term multipotent potential in transplantation assays [ 9, 33], whereas the reconstitution potential of PI-MECs or luminal populations identified by other methods is more limited [ 11, 33], suggesting that some lineage restriction remains even in transplantation assays.

Because our data suggested that the reconstitution potential of wt HSPCs is limited by Bim-dependent apoptosis under conditions of reconstitution stress, we transplanted rate limiting numbers of wt or bim −/− BM-derived cells simultaneously with 200,000 Ly5.1+ BM competitors.

The transient overexpression of Run1t1, Hlf, Lmo2, Pbx1, Prdm5, and Zfp37 in committed myeloid and lymphoid progenitors triggered the formation of so-called induced HSCs (iHSC), which possess multilineage reconstitution potential, while being serially transplantable and showing a gene expression profile similar to in vivo HSCs (Riddell et al, 2014).

Although deficiencies in these pathways did only partly deplete stem cell reserves with age, stem cell functional capacities were severely affected under conditions of stress, leading to loss of reconstitution and proliferative potential, diminished self-renewal, increased apoptosis and, ultimately, functional exhaustion [12], [13].

Contrary to acute allograft rejection occurring in humans [ 47], no B lymphocyte signatures (CD20, immunoglobulin genes) could be observed clearly demonstrating that reconstitution of a potential B cell response could not have been responsible for the inflammatory switch and the production of CXCL and CCL chemokines [ 48].

Hospital-acquired infections already kill 100,000 people a year, and a recent report by the Centers for Disease Control and Prevention documenting the first case of a vancomycin-resistant staph strain from a Michigan patient is much more troubling than the potential genetic reconstitution of viruses like smallpox.

Further studies are needed to examine the efficacy of glucagon used for several days after reconstitution and to assess potential cytotoxicity at clinically appropriate concentrations.

The two interacting partners, linked to the YFP fragments, bring the fragments into immediate vicinity of each other which leads to the reconstitution of its fluorescent potential.