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The reconstituted formulation contained 10 mg/mL GAA, 50 mM sodium phosphate, 4% mannitol, and 0.01% Tween-80 at pH 6.2.
The final reconstituted formulation at concentrations of 0.4 mg ml−1 or lower is stable for at least 6 months when kept at room temperature and protected from light.
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Five μl of 6 M HCl was added and mixed by vortexing to 300 μl of Visudyne aqueous solution of clinically reconstituted liposomal formulation, in which the VP concentration was 2 mg/ml.
When trehalose or mannitol was used as stabilizing agent, the formulation reconstituted from a lyophilizate displayed thermosetting properties and was still injectable, paving the way to the development of a clinically utilizable, novel chitosan thermosetting hydrogel.
The original formulation is reconstituted with sterile water for injection (SWFI), whereas the new formulation is reconstituted with a solvent containing histidine.
The intravenous antibiotic formulations were reconstituted according to the manufacturers' recommendations and diluted in water in order to reach stock solution aliquots of 1 mg/mL, stored at -20°C.
Both formulations must be reconstituted before use.
Usually, this approach will either give optimal or suboptimal solutions, depending on how close the restructured or reconstituted problems are to the original problem formulation.
The first was a new once-monthly formulation, consisting of EQW microspheres reconstituted in a triglyceride-based diluent.
The Ultra Rice technology is a formulation and method for creating reconstituted rice grains packed with micronutrients such as iron, thiamin, zinc, and folic acid.
A liposomal formulation of verteporfin (Visudyne®, Novartis Ophthalmics, Hettlingen, Switzerland) was freshly reconstituted from powder as previously described [ 32] and injected (0.5 μl) into the tip of the ear dermis using a microsyringe (Hamilton, Reno, NV, USA) (Fig. 1a).
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