These values are low relative to the calcium concentrations believed to elicit release at hair cell synapses and thus difficult to reconcile with a role for otoferlin as the calcium sensor for neurotransmitter release.
The fact that both metabolites are generated extracellularly is impossible to reconcile with a role in intracellular signal transduction, and it has therefore been suggested that cADRP functions exogenously in stimulated B cells 6.
In Tfp, however, the finding in N. gonorrhoeae that wild-type levels of piliation can be restored in the concurrent absence of PilH, PilI, PilJ and PilK when pilT is also mutated (Winther-Larsen et al., 2005) seems difficult to reconcile with a role of these proteins in initiating filament assembly.
However, as the distribution of maltose between cellular compartments can vary in response to light conditions [57], [58], [59], [60], [61], and we show that the strongest accumulation occurs coincident with starch breakdown in the dark (Figure 9), such dramatic changes in abundance and localization are not easily reconciled with a role as a compatible solute.
These observations can be reconciled with a role for EBV in BL pathogenesis by supposing that EBV somehow increases the likelihood of generating cellular genetic changes, most importantly MYC-activating translocations, which drive lymphoma development.
"How do you reconcile your role as a commander in chief with your aspirations to promote a more peaceful world at a time of war?
How did you reconcile your role as an "ambassador" vs. reporter?
Taken together, our results can be reconciled by proposing a role for arginine methylation in the regulation of many protein protein interactions (including but not limited to the TDRD3/DDX3 interaction) important for SG dynamics.
"We understand it may sometimes be challenging to reconcile the role [held by Kroes] as a former commissioner with the temptation to publicly express the views of those – in Silicon Valley or elsewhere - who oppose the commission's decisions," he said.
