We feel that the impact of PSF modelling on variability for clinical data has yet to be explored fully, and while this is beyond the scope of this study, it is recommended that caution is observed when applying PSF modelling for assessing response to treatment with follow-up scans.
Some investigators, therefore, still recommend that caution should be taken when using these products, in particular with their chronic use.
Costello et al [ 37] recommend that caution should be exercised about the clinical significance of less serious symptoms unless longitudinal studies prove that these are associated with a risk of future clinically significant disorders.
However, because concerted evolution of duplicated control regions may be widespread, we recommend that caution should be exercised when using the control region as a molecular marker in population genetic or phylogenetic analyses.
In recent years it has also been recommended that caution should be demonstrated when angiotensin II blockers are used in the same type of patients but the evidence is based only on few cases.
Given the multiple issues identified regarding tests of statistical significance in this context, we recommend that caution should be exercised when interpreting any measures of a psychometric property which rely on tests of statistical significance.
Finally, we recommend that caution should be taken when estimating the relationships between climate variables (and climate change) and dengue in the following aspects: use of time lags, the analysis of extreme climatic events, the differences between seasonal and long term trends, nonlinear effects and threshold effects in the associations.
Recognizing the more concerning potential for hypoxia by restricting inspired FiO2, the investigators recommended that clinicians take caution in ordering deliberate decreases in FiO2 to avoid hyperoxia and that related protocols be revisited.
The authors noted how drug users are often falsely reassured by the reactions of other people they are using drugs with, and recommended that clinicians caution patients that interactions between street drugs and medications can be unpredictable, sometimes dangerous, and differ widely between individuals.
The C.D.C. would never recommend that, she cautioned, "because you still should vaccinate high-risk people".
