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Although we did not observe hemodynamic failure, including arrhythmia or hypotension, in our patient, we should have recommended interruption of the operation a little earlier.
For men with metastatic CRPC and bone metastases responding to a treatment, 58% of the panel were of the opinion that osteoclast-targeted therapy should be continued at the same schedule, whereas 26% voted for decreased frequency and 16% recommended interruption or discontinuation of the osteoclast-targeted therapy.
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Current guidelines recommend interruption of myorelaxant infusion and clinical evaluation of the sedation level when the muscle blockade has been reversed.
The ICRP does not recommend interruption of breastfeeding after FDG administration since little FDG is excreted in the milk [ 25].
In addition, the DMSC may recommend interruption of the trial at any time if safety concerns arise upon SAE evaluation or due to other reasons.
Accounts in the literature on the anaesthetic approach to nursing mothers are sparse [ 19, 24, 25]; guidelines do not reflect this setting, and textbooks recommend interruption of breast feeding for 24 h.
Conventionally, guidelines recommended temporary interruption of antithrombotic therapy for endoscopic interventions [ 1].
Based on the results of these two safety evaluations, the DMSC will recommend continuation, interruption, amendment or termination of the trial.
Four programmatic steps - mapping, mass drug administration (MDA), surveillance and verification - were recommended to achieve transmission interruption.
Moreover, in case of occurrence of adverse events, if not severe, a dosage reduction may be recommended instead of temporary interruption.
Daily sedation interruption (DSI) recommended in the 2002 guidelines became a key strategy after Kress and colleagues [ 34] reported significant reductions in ventilation time and ICU stay in a single-center 128-patient randomized trial.
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