We recommend intensification of control interventions for several years to further reduce incidence, prior to considering an elimination programme.
Although most guidelines recommend intensification of insulin treatment by using more than one injection, data are very limited supporting this approach.
To increase diagnostic yield, we recommend intensification of efforts to obtain blood cultures in the absence of antimicrobial drugs and increase of laboratory capacity to test for zoonotic bacteria (15 ).
8 Following initial treatment with metformin, the ADA, in contrast, recommends intensification with either basal insulin or a sulfonylurea (both Tier 1, or well validated therapies), pioglitazone or a GLP-1 agonist (both Tier 2, or less well validated therapies).
It is of interest that using large sonotrodes may reduce the intensity of bubble collapse and hence are thus not recommended for intensification [ 99].
Despite having HbA1c levels for which diabetes guidelines recommend treatment intensification, few people appeared to undergo intensification (4, 6, 7).
However, given the urgent need to include feedbacks and transient dynamics, we strongly recommend the intensification of the development of process-driven models for the conservation of protected areas under climate change.
However, in patients with HbA1c ≥7.5% in conjunction with metformin, either DPP-4 inhibitors, SGLT-2 inhibitors, or GLP-1RAs are recommended as therapy intensification.
The letter will indicate the stage of diabetes intensification recommended and will include a standardized Home Care order set for that stage.
We recommend upland agricultural intensification and diversification based on improved soil fertility through optimized organic and inorganic inputs and fire-less land management that encourages the re-establishment of nutrient stocks.
