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These study inefficiencies were reviewed by the study Principal and Co-Investigators, who made recommendations for adjustments.
Investigation of differences across points of encounter may enable recommendations for adjustments to be made more reasonable from the perspective of hospital staff: that is, by considering differences in the nature of interactions and requirements across steps in the patient journey.
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Potential recommendations for dose adjustment to compensate for these interactions have not been elaborated.
Although there are no specific recommendations for dosage adjustment in patients with renal insufficiency, candesartan should be used cautiously with close monitoring after initiation and during dose titration.
It consists of two pages of simple recommendations for the adjustment of insulin dose in a basal-bolus schema of insulin therapy including one injection of insulin lispro (or insulin aspart) before each meal, and one injection of insulin glargine before going to bed.
The chosen literature references resulted in bigger differences in recommendations for drug dose adjustment than the different equations used for estimating eGFR alone.
In addition to the estimated kidney function, the chosen literature source had a strong impact on the recommendations for drug dose adjustment in our study population.
As several equations for quick assessment of kidney function by estimating glomerular filtration rate (eGFR) and several different clinical recommendations for drug dose adjustment in renal failure are published, choosing the correct approach for drug dosage is difficult for the practitioner.
The aims of our study were 1) to quantify the agreement between eGFR-equations grouped by creatinine-based or cystatin C-based and within the groups of creatinine and cystatin C-based equations and 2) to investigate whether the use of various literature and online references results in different recommendations for drug dose adjustment in renal disease in very elderly primary care patients.
The aims of our study were to quantify the agreement between eGFR-equations grouped by creatinine-based or cystatin C-based and within the groups of creatinine and cystatin C-based equations and to investigate whether use of various literature and online references results in different recommendations for drug dose adjustment in renal disease in very elderly primary care patients.
Recommendations for diabetes medication dosing adjustments tailored for both type 1 and type 2 diabetes patients are also outlined.
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