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Despite the ICMJE's recommendations, considerable variability remains in requirements by different journals: some require that ethics approval is stated in the methods section of the manuscript, whereas others require only a separate signed statement from the author; others simply state that studies must have ethics approval but do not mention a method of documentation.
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In the listing recommendations reviewed, considerable variability exists in the clinical evidence considered by PBAC, CDR, and NICE for drug-listing recommendations.
Heterogeneity is highlighted by the individual Forest plots where inflated I values of over 85% are represented for all recommendations, denoting considerable heterogeneity.
Despite the guidelines' strong recommendations, a considerable portion of patients in everyday clinical practice is, for various reasons, not sufficiently hydrated [ 24, 51].
This is in line with research showing that general practitioners who try to provide good diabetes care via the presentation of evidence-based recommendations experience considerable frustration when patients do not adopt or adhere to these recommendation [ 11].
What appears to be the report's most benign recommendation carries considerable risk.
Though a staff recommendation carries considerable weight, it does not necessarily mean that Mr. Pate will reach the same conclusion, antitrust lawyers said.
Those recommendations, made with considerable input from the teams, included a drop in maximum wind limits to 23 knots from 33 knots — about 26 miles per hour from 38 miles per hour — as well as technical modifications intended to make it easier and safer to steer the large and fast catamarans.
Such recommendations require a considerable amount of expert validation and, probably, some changes in VCM hierarchy.
Parents acknowledged that expecting all family members to adopt recommendations was a considerable obstacle.
In part due to the lack of clear recommendations, there is considerable heterogeneity in real clinical practice in terms of how and when to adopt a new pharmacological approach in those patients who have not responded adequately to first-line treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com