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In general, there is little high-quality evidence from randomized clinical trials to support specific interventions for HFSR related to any kinase inhibitor, with most recommendations being based on empirical experience and expert opinion [ 28– 39].
The emphasis on internal validity has contributed to the failure of EBM, as recommendations – being based on experimental designs where variables and confounders are controlled (RCTs) – often fail to be translatable into practice because the research context does not reflect real world clinical practice/reality [ 67, 68].
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