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Based on WHO recommendations, an intervention may be considered cost effective if the cost per QALY is less than the country's GDP per capita [ 35, 40] C1 is the cost of the new intervention, and E1 is the effect of the new intervention, whereas C0 and E0 are the cost and effect of the base case or comparator.
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Other studies have only identified the health risk factors and made recommendations for an intervention programme [ 4, 10].
Fifty-nine diabetic subjects were randomized to a control group receiving standard lifestyle recommendations or an intervention group assigned to three supervised walking sessions per week and counseling.
This assumption was based on World Health Organization recommendations that an intervention with costs per Disability Adjusted Life Year averted of less than GNI per capita can be considered highly cost-effective [ 20].
The senior author of the study, Dr. Adnan Custovic of the University of Manchester, said the findings did not lead to any recommendation for an intervention to prevent asthma.
We marked a cell 'X' when a commonality (a correspondence) was found between a patient recommendation and an intervention component.
Each column represented a recommendation for an intervention component derived from the qualitative review, while each row represented whether an individual trial's intervention matched any of the recommendations.
Following the World Health Organization recommendation, we considered an intervention "highly cost-effective" if it was less than one time the per capita gross domestic product (GDP) in Mexico per QALY gained (equivalent to US$ 9,766) and "not cost-effective" if it was greater than three times the per capita GDP per QALY gained (equivalent to US$29,300 [16]].
A strong recommendation for using an intervention was given when the benefits clearly outweighed the risks for most if not all patients, with high-quality evidence supporting that recommendation.
As in the first version of these guidelines, when recommendations are made for an intervention supported by one or more trials done with a specific product, we mention the generic drug name followed by the brand and company indicated in the paper reporting the study results.
Despite the fact that many factors play role in formulating CPG recommendations, we show that when the quality of evidence is higher, the probability of making a strong recommendation for or against an intervention dramatically increases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com