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Back in 1992 Sir Adrian Cadbury ushered in a boardroom revolution in Britain when he urged companies to comply with his recommendation to split the two jobs or explain why they had not.
For the exomeCopy analysis, the recommendation to split long exons into smaller units (and therefore, get more uniform numbers of reads in each bin) increased the number of CNV calls and the concordance with DGV dropped, strongly suggesting that this step did not improve the overall accuracy.
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Therefore, we didn't try to split recommendations.
Furthermore, a higher peak effect of the evening biphasic insulin aspart dose in this study led to recommendations by the authors to split doses 2/3 am and 1/3 pm to avoid increasing the risk of nocturnal hypoglycaemia.
The letter was in response to recommendations by two proxy advisory firms, Institutional Shareholders Services and Glass, Lewis, to split the jobs and to withhold support from certain directors.
It decided that regulators should have the power to split up only individual banks, and has rejected the recommendation that they should be able to force the entire banking sector to split its wholesale from its retail operations.
We expanded the 12 recommendations to 15, splitting those with double responses (e.g. 'Offer diet and physical activity counselling to women' was split to: i. 'Offer diet counselling to women' and ii. 'Offer physical activity counselling to women').
Since the steps we need to execute are time- and resource-consuming, we decided to split WR in two phases: (1) preparation and (2) query and recommendation.
The reaction tends to split between disappointment with the lack of change and outrage when recommendations actually do change -- how come we were advised something that's now deemed untrue?
To split?
Only to split again.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com