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Would you recommend this trial to a relative?
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We recommend that this trial should be a randomized controlled trial with appropriate allocation of patients and blinding of patients and care providers and outcome assessors, and that it should include patient-important outcomes.
We recommend this design for gear trials in variable environments, if the codends can be swapped quickly and especially if the trial involves hundreds of tows.
On the basis of these results, the data and safety monitoring committee recommended halting this trial.
Although the tube design has changed and daily antibiotics are no longer recommended, this controlled clinical trial calls into question whether the benefits of ear tubes outweigh the risks.
The overall response rate (ORR) in this group was 38%, and the Data Monitoring Committee recommended the trial be modified.
The committee recommended the trial be continued and the final results (no difference between the two therapies) vindicated this apparent chance finding at interim analysis [ 23].
For very severe cases, MacGregor said, she might recommend a trial course of isotretinoin, a vitamin A derivative, but acknowledged that it doesn't always work.
We recommend clinical trial assessment of inorganic arsenic in the treatment of advanced breast cancer.
This imbalance in mortality rates led the data and safety monitoring board to recommend early trial discontinuation after inclusion of 627 patients (310 dronedarone, 317 placebo) [ 12].
Similarly, 60% of respondents would not currently recommend a trial of any cannabinoid preparation, with 20% each agreeable to recommend a trial of pharmacologic cannabinoids only, or pharmacologic and/or medical (herbal) cannabis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com