The DCL enzymes and functional modules undoubtedly evolved to efficiently handle a wide variety of natural substrates many of which have probably not yet been identified, and it is likely that the enzymes recognize signature structural features of their preferred substrates.
TLRs are pattern recognition receptors (PRR) that recognize "signature patterns" of microbes, called pathogen-associated molecular patterns (PAMPs).
This procedure is well suited to recognizing signature features and for clustering drug responses according to their features rather than the strength of their response.
Autophagy plays a key role in recognizing signatures of viral infection, and represents a critical effector mechanism to restrict viral replication.
Moreover, autophagy may protect against virus infection through recognizing signatures of virus infection, degradation of viral components (xenophagy), and restriction of virus replication (Lee and Iwasaki, 2008), and Hdac6 promotes autophagy and stimulates autophagosome-lysosome fusion and substrate degradation (Lee et al., 2010).
Our immune system identifies pathogens in part by recognizing signatures present in microbes, so-called PAMP, via specific germline encoded PRR [ 1].
MY old dry cleaner, Kevin Hwang, may have recognized the signature ink stains on my favorite shirt before he recognized me.
A handful of Higgs bosons were discovered earlier this year by algorithms that recognized their signature among terabytes of data.
However, it is also used by attackers to conceal malicious JavaScript code and prevent it from being recognized by signature based detectors or detectors based on lexical analysis of code (such as [7]), and to reduce readability by a human security analyst.
So when I was driving through downtown and saw this mural, I immediately recognized his signature style and was not surprised to see people taking pictures and 'selfies' with the Bernie Mural.
