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PBMC from animals r00078 and r01064 also recognized overlapping 15-mer peptides containing this 10-mer sequence (see below), suggesting that all three ECs responded to this same epitope.
A reduction in the binding signal >50%% in the presence of the second antibody was taken to indicate that the antibodies recognized overlapping epitopes.
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C-strain-induced anti-sera and hyper-immune sera cannot recognize overlapping peptides that cover the E2 N-terminus, while MEVABC is able to elicit high levels of peptide-specific antibody response.
At cell surface, both HFE and diferric-iron-loaded transferrin (Fe2-Tf) recognize overlapping regions on TfR1, which results in competition for binding to this receptor [10].
RC and RD antibodies recognize distinct epitopes on PcrV, while DA and DB recognize overlapping or identical epitopes on PopD.
The 2 different methodologies showed relatively weak but statistically significant correlation with each other, suggesting that the 2 techniques are capable of recognizing overlapping cell populations.
FcγRs and C1q recognize overlapping regions in the Cγ2 domain, within the fγ2 β-strand, the b6 bend, and the lower hinge region, which are adjacent to each other in three-dimensional space (28, 37).
Three types of PCD have been well characterized in metazoans, including type 1 PCD, or apoptosis [6], [7] however, it is now recognized that overlapping pathways leading to different types of PCD death exist, and more complex nomenclature has been suggested [8].
These two antibodies recognized an overlapping band at ~28 kDa in COS-1 transfectants (Supplementary Fig. 2b).
The extended histological spectrum (currently 4 MB variants are recognized) shows overlapping features on MR imaging when comparing classic MB and MB variants.
Initial consensus statements focusing on sepsis definitions employed vital sign abnormalities and leukocytosis [ 4], but it is well recognized that overlapping with noninfectious etiologies exist [ 21].
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