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In addition to their physical applications, phenothiazine derivatives have been recognized as potent anti-psychotic [20], anti-infective [21], antioxidant, anti-cancer [22] and anti-Parkinson agents [23].
Nannochloropsis gaditana is a microalga characterized by its high lipid content and as an important source of carotenoids, recognized as potent natural antioxidants.
Both SS and Fas activation are recognized as potent inducers of endogenous ceramide.
Plant secondary metabolites, particularly polyphenols, are also increasingly recognized as potent antimicrobials [ 11].
IgG autoantibodies and immune complexes have long been recognized as potent pathologic triggers of inflammatory responses.
Independent of their antibiotic properties, doxycycline and other members of the tetracycline family of antibiotics have been recognized as potent anti-inflammatory and immunomodulating agents [ 28– 31].
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Norepinephrine (NE) is recognized as a potent vasopressor used in septic shock to reverse hypotension.
Growth hormone (GH), in the recent past, has been recognized as a potent steroid stimulating hormone independent of gonadotropin (GtH).
Interleukin-8 (IL-8, also known as neutrophil-activating peptide 1, NAP1 and CXCL8, CXC chemokine ligand 8) is recognized as a potent effector of neutrophil functions.
Spider peptide and protein toxins are recognized as highly potent and specific molecular tools that modulate neurotransmission via interaction with a variety of ion channels, receptors, and transporters in vertebrates and invertebrates.
Age (mean 32.7 years) has already been noted as a factor; others may be the nature of the work – manual labour for two thirds, often heavy – and, maybe more contributory, the fact that these workers rotate weekly through early, late and night shifts (schedule disturbances have long been recognized as a potent migraine trigger [12]).
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