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For the diagnosis of malignant human tumors, a change in cell elasticity, within tissues, has recently been recognized as a marker of metastatic potential.
Recently, lysozyme was identified by complementary DNA microarray analysis as one of several differentially expressed genes noted to influence hatchability and recognized as a marker candidate for animal marker-assisted selection.
Hypercapnia has long been recognized as a marker of poor prognosis in patients with COPD [1], with those requiring mechanical ventilation being particularly challenging to wean [7, 8].
Notably, CD133 has been recognized as a marker for developing epithelium [45].
In addition, gp240 is recognized as a marker for multipotent early oligodendrocyte progenitors in normal CNS [15], [16] and its increased co-expression with CD44 has been proposed as progressive marker of malignant gliomas [17].
Elevation of circulating amino acids such as alanine and BCAAs has been recognized as a marker of protein overfeeding and is often associated with an insulin resistant state, for instance, in obese individuals [40], [41].
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Although, ALDH is not recognized as a generic marker of stem cells [22], it appeared to be a valuable functional marker for isolation of cells with tumour-initiating, metastatic and drug-resistance properties in cancers that follow a CSC model, like leukaemia [23] and breast cancer [9], [10].
Robin Lakoff, a professor of linguistics at Berkeley, read a partial transcript of Clinton's remarks and was struck by the recurrence of something else: the phrase "you know," which in her line of work is recognized as a "discourse marker" or a "pragmatic particle".
Since ∆PCO2 is now widely recognized as a valuable marker to evaluate tissue perfusion in septic shock, a clinician should be aware that acute changes in pH or PaCO2 induced by hyperventilation could impact ∆PCO2 independently of changes in tissue perfusion.
It was first recognized as a surface marker for haematopoietic stem cells [14], [15].
Decreased levels of α-synuclein in CSF, and an elevated level of the oligomeric protein in plasma have been reported [12], [13], but neither is recognized as a diagnostic marker.
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