Although there remains a possibility that our antibodies do not recognize alternatively-spliced isoforms, recombinant hRasGRP4 splice variant 6 with C-terminal V5 tag was recognized clearly by our anti-hRasGRP4 antibodies and by anti-V5 antibody (data not shown).
First, we used an Ab that recognized all the alternatively spliced isoforms of CD45.
Furthermore, we surmise that PRES is likely more prevalent than previously thought in the ESRD population, and only extreme cases heralded by seizure are brought to medical attention, or alternatively, recognized by healthcare practitioners.
The protein sequence encoded by exon 5 might represent a binding motif that mediates protein protein interactions with specific co-factors, as one recognized function for alternatively spliced isoforms is to remodel the protein protein interaction network [69].
The monoclonal antibody F8 was chosen as fusion partner of proven tumor targeting performance, which recognizes the alternatively-spliced EDA domain of fibronectin, a marker of angiogenesis.
The L19 and F8 human antibodies recognize the alternatively-spliced extra-domain B EDB) and extra-domain A EDA) of fibronectin [ 9, 10], respectively, which are not present in plasma fibronectin and which are almost undetectable in normal adult tissues.
Alternatively, investors recognized that insurance stocks would benefit from rising premiums charged to anyone with an asset to protect.
The differential regulation of MAGE-A1 gene expression could be explained by a separate site in MAGE-A1 promoter that could be recognized by a BORIS alternatively spliced isoform with different sequence specificity.
Currently, we can suggest either direct interaction of BORIS with Sp1 generating a DNA kink that diminishes transcription, or a separate site in MAGE-A1 promoter that could be recognized by a BORIS alternatively spliced isoform with different sequence specificity.
Neither the Geneva convention nor its commentaries recognize or use alternatively the natural growth or physical-extension qualifier to justify the transfer of parts of the occupying-power population into the occupied territories.
For example, TRAB1 can alternatively recognize the two motifs [ 25] and Rap2.4b can take over DREBP and ERF-function if overexpressed [ 27].
