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We also recognize that the sample size relative to the usability study and the heuristic evaluation is small.
We recognize that the sample size was small, although sufficient to determine significance and the lack of a control group.
Although this sample size was robust enough to detect formaldehyde-responsive miRNAs, we recognize that the sample size may have limited the power to detect additional changes in miRNA expression.
We recognize that the sample sizes of some of the delay calculations (especially total delay) for 6 of the 10 cancer types in the study (Table 2) are small (due to missing data and a small number of these cancers in Denmark).
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However, we recognize that the sampling method and location limits its generalizability to the larger Malaysian population.
Values in parentheses are percentages relative to control value (100%%) bThe number of controls was determined without water extracts of A. camphorata According to the judgment criteria in the method, it would be recognized that the sample possessed mutagenic ability when the number of His+ revertants induced by the sample was more than twice the number of spontaneous revertants [ 18].
Although the protocol identified primary and secondary endpoints, the analysis plan recognized that the sample size did not provide adequate power to detect statistically significant differences, and so the overall pattern of results was to guide the dose selection for the subsequent confirmatory study.
During development of the popLowess strategy, we recognized that the sample-specific cut-off value could be used to assess noise level in data and to assign thresholds for copy number imbalances on a sample-specific basis.
We did not find any 15q13.3 (BP4–BP5) deletions in our cohort of 113 individuals; however, we recognize that the small sample size of our study cohort limits the power to detect this rare rearrangement.
We also recognize that the taxon sampling and genetic component of this research are limited, however, we have sampled across the diversity of one of the most diverse groups of organisms on the planet.
First, although the study sample provided 80%% power to detect a minimum risk of 1.5, we recognize that this sample size is limited to detect smaller effect sizes that are expected on average for complex traits [ 44].
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