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We show that compounds assembled on-site that recognize structure have the highest potencies amongst small molecules and are similar in potency to a vivo-morpholino modified oligonucleotide that targets sequence.
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This is important to the study of the brain since it allows us to recognize structures that play key roles in certain fundamental mental processes.
We have demonstrated that transposon Tn7 will recognize structures that form spontaneously in GAATTC repeats and insert in a specific orientation within the repeat.
These receptors recognize structures that are conserved among microbial species, which leads to the upregulation of inflammatory gene transcription and the initiation of innate immunity.
Conversely, they may fail to interact stably with [ 26], or recognize structures that differ from, the mGTP-cap-structure [ 28, 33, 34] preventing isolation using standard mGTP-affinity resins.
Since T cell receptors recognize structures rather than amino acid sequences and both peptides of 20 residues are about 70% different we did not use an unrelated peptide as control.
In particular, it has been postulated that they recognize structures presented by microorganism as well as by stressed, abnormal cells, preventing the entrance of pathogens into the subepithelial layer by a cytotoxic mechanism against infected and stressed epithelial cells [ 12].
GS-I bound to Galα1-3Gal as expected, but it did not recognize structures with terminal β-Gal such as the Thomsen-Friedenreich (TF) antigen (Galβ1-3GalNAc atoached to proteins by an α O-serine or O-threonine linkage).
For example, the misassignment of atom charge or bond-stereo would not be so critical for finding molecules similar to the recognized structure in a database.
Taken together, these studies suggest that a small molecule that recognizes structure may be more well suited for targeting highly structured RNAs that require strand invasion by a complementary oligonucleotide.
He thus recognized structures of imperial origin.
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