Sentence examples for recognize modified from inspiring English sources

Another possibility would be the interaction with modified histones: H3K27me1, H3K9me3, and H4K20me3 are enriched in chromocenters [37], and the PWWP domain has been shown in certain proteins to recognize modified histones [38], [39].

Type IV restriction endonucleases recognize modified, typically methylated, DNA.

Semisynthesis of site-specifically acetylated and phosphorylated H2B informed on the ability of Mst1 kinase and a commercial antibody to recognize modified targets.

Comparing the chromatin association of a specific protein with differently modified chromatin regions could be accomplished by using antibodies that preferentially recognize modified epitopes on core histones for the initial immunoprecipitation step (Fig. 1).

The binding affinity of dSfmbt for methylated lysines in the histone H3 and H4 N-termini is in the low micromolar range and is thus comparable to that of heterochromatin protein-1 or the double bromodomain of TAF250 that recognize modified histone lysines in specific sequence contexts (Ruthenburg et al, 2007).

New therapeutic strategies aim to selectively target proteins that recognize modified histones, such as BET (bromodomain and extra terminal domain) family proteins, or alter DNA methylation in a specific way through artificial transcription factors or the thymine DNA glycosylase (TGD) enzyme.

The anti-oxLDL antibody FOH1a/DLH3 recognizes modified apoB in oxidized LDL [65].

Indeed, BCL9 is recognized as an adaptor that helps PYGO in recognizing modified histone H3 tails by their plant homeodomain (PHD) fingers [ 49].

Moreover, many PICH-positive fibers were decorated with antibodies recognizing modified histone H3, di-, or trimethylated at lysines 4 (2mH3K4) and 9 (3mH3K9; Fig.  1b and c).

Genomic DNA or RNA from several pathogens, including viruses, bacteria, and protozoa, is sensed and recognized by TLR9, which is also capable of recognizing modified forms of DNA such as unmethylated CpG islands.

The activated T cells recognizing modified peptides can provide the help necessary for the activation of these B cells, resulting in the production of antibodies directed towards modified self.