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Mafs unique DNA-binding domain contains a highly conserved extended homology region (EHR) that allows to recognize longer DNA sequences than other basic leucine zipper (bZIP) transcription factors.
While the site does allow for some Boolean searches (those directed by qualifiers such as "and", "or" and "not") to narrow search results, some users complain that it does not recognize longer search strings.
GacH was recently shown to recognize longer acarbose homologues but exhibits only low affinity to acarbose [ 68].
It has been speculated that a number of ZFDs in tandem recognize longer DNA sequences (Alwin et al., 2005; Beerli and Barbas, 2002; Beerli et al., 2000; Kim and Pabo, 1998; Liu et al., 1997; Pabo et al., 2001).
Similar in concept to TALEs, eukaryotic zinc fingers (ZFs) are small (∼30 amino acid) modular domains that bind to 3 bp DNA regions with engineerable sequence specificity and can be linked into multifinger arrays that recognize longer sequences.
Taken together with the aforementioned multiplicity of ZFDs in chimeras, these findings suggest that chimeric zinc finger transcription activators and zinc finger transcription repressors potentially recognize longer DNA sequences.
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Although the effect of adding the error predicted by an ANN reduced with lead time, probably due to the difficulty in recognizing longer patterns by neural networks, the predictions were fairly good till five time steps ahead.
MDA-5 recognizes longer RNAs (>1 kb) that are encoded by positive-stranded viruses such as the picornavirus encephalomyocarditis virus [85].
We therefore examined chondrocytes from OA and non- or early OA patients for the presence of dsRNA intermediates with an antibody that specifically recognizes longer stretches of dsRNA.
Instead they should recognize the longer game: defeating a major infectious disease, and securing this generation's legacy as beginning the end of AIDS.
But do they recognize the longer-term problem: that their refusal to share the affairs of state with their own people is the greatest peril of all?
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