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For instance, one of the known disease signs in depression is psychomotor retardation, involving a recognizable alteration in locomotor activity, such as a slowing down of movement, which is observable by others [9].
At the age of 8 weeks, we have observed no readily recognizable alteration in the behavior of the mice used in this study.
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Enlargement (>50-fold) of normal terminal duct lobular units (TDLUs) by hyperplastic epithelial cells is one of the most common and earliest histologically recognizable alterations with premalignant potential.
Taken together, this evidence strongly supports the notion that exposure to chemicals classified as endocrine disruptors can also cause damage to DNA, but to date there have been no examples of genetic damage occurring in organisms with recognizable alterations to their endocrine systems in vivo.
Pseudotachylytes are rarely preserved in a recognizable form due to recrystallization, alteration, and subsequent deformation by cataclastic and crystal-plastic mechanisms (Kirkpatrick and Rowe 2013).
However, all factors contribute to a physiological alteration that is recognizable as a systemic illness.
The model of breast cancer progression via sequential acquisition of selectively advantageous molecular alterations with morphologically recognizable phenotypes is a convenient conceptual framework.
In our analysis, the absence of recognizable prominent differences in molecular alterations based on BRCA1 mutation status would be in line with previous clinical data suggesting that BRCA1 status per se might not play a major role in conferring a distinct prognosis within basal-like disease.
Since all of these genomic alterations leave a distinct and recognizable signature on WGS mapping, detection and quantitative analysis of PV caused by these alterations is feasible using very similar methods, and might be used to better comprehend the inherent genetic variability in seemingly clonal bacterial populations.
The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions.
As a result of the growth advantage of dysplastic cells over their normal neighbors, the morphological counterpart of molecular alterations leads to progressive cytological and architectural derangement recognizable as the adenoma-carcinoma sequence [1], [2].
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