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Along with recruitment and recognition, retention is a big problem among volunteers.
For secretory and membrane proteins, the molecular machinery involved in the recognition, retention and dislocation of aberrant proteins has been identified to a certain detail (Carvalho et al. 2006; Denic et al. 2006; Hirsch et al. 2003; Ismail and Ng 2006; Katiyar et al. 2005; Li et al. 2006; Lilley and Ploegh 2004; Schuberth and Buchberger 2005; Tsai et al. 2002; Ye et al. 2003, 2004).
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Additionally, a stressful experience before the retention test can impair recognition memory at longer retention intervals (hours) but not at 5 min [64,65].
In this way, Phase 1 examined object recognition memory with a retention period of less than 1 min, while Phase 2 examined object recognition memory with a retention period of 31 minutes for each familiar object (20 mins plus the 11 mins taken to complete Phase 1).
This test measures memory retention and recognition memory in mice and was performed in accordance to published protocols [ 45].
The hippocampal findings prompted Experiment 2. Here, rats with hippocampal lesions were tested in the dark for object recognition memory at different retention delays.
Of particular note was that he displayed completely normal levels of forced-choice recognition memory after a retention delay of 24 h, which was demonstrably sufficient to eliminate ceiling effects (Vann et al., 2008).
We tested whether these striatal VAChTD2−Cre−flox/flox mice would display normal short-term (5 or 15 min retention delay) and long-term (3 h retention delay) object recognition memory.
Although the results of the object recognition task were consistent with the previous literature, there was no evidence of an effect of NR2B over-expression on the retention of odor recognition memory in the specific task performed.
A plausible interpretation of our findings is that in wakefulness, ongoing sensory stimulation interferes with the visual memory; sleep, by sheltering the visual memory from sensory interference, temporarily prevents memory loss, but subsequent wake washes out the effects of sleep, with the result that sleep has no long-lasting impact on retention of face recognition memory.
Administration of Kihi-to for consecutive 3 days resulted in marked improvements of Aβ(25 35 -induced 25 35 -induced memory acquimpairmentsmory retentinn, and object recognition memory in mice.
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