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Perpetuation of proinflammatory responses could also be, at least in part, determined by cross recognition of sequence motifs shared between self and exogenous proteins [28] [30].
This observation is consistent with involvement of UHRF1 in methylation maintenance of the entire genome, where specific recognition of sequence context outside of the mCpG site would be disadvantageous.
The regulatory mechanism would operate through the recognition of sequence elements located at the beginning of the coding region and in the 3´ UTR of the tubulin genes [ 31].
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The potency and robustness of gene modulation by these RNAs suggests that natural mechanisms may exist to facilitate recognition of sequences within gene promoters by endogenous small RNAs.
Characterization of binding sites is best inferred from recognition of sequence-specific contacts, mostly called direct recognition or direct readout.
FokI cleaves only when present as a dimer, allowing precise recognition of sequences on opposing DNA strands.
However, in the heterogenous format the recognition of target sequence occurs on a specific probe sequence linked to a solid support.
The application of multilocus sequence typing (MLST), typically 7 loci, enables the recognition of bacterial sequence types (STs) and clonal complexes (CCs).
The ERRs also have a marked preference for the recognition of the sequence TCAAGGTCA, which is referred to as an estrogen-related response element (ERRE).
However, development of this approach into a viable device necessitates reliable analysis techniques which allow recognition of the sequence of the written electrical pulses via shape and size of the resulting domain.
Specific regions of the periodic table can be referred to as blocks in recognition of the sequence in which the electron shells of the elements are filled.
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