Acquired or de novo resistance to platinum-based chemotherapy is commonly observed in ovarian cancer, with numerous underlying mechanisms now proposed to explain this phenomenon, including drug inactivation, elevated resistance to apoptosis, decreased recognition of DNA damage, and increased DNA repair [ 8, 9, 53, 54].
Nijmegen breakage syndrome 1 participates in the recognition of DNA damage and subsequent recruitment of MRE11 and RAD50, forming DNA repair complexes at the sites of DSB damage (Kobayashi et al, 2004).
As the recognition of DNA damage is highly sensitive with a low threshold for triggering DNA damage responses in dividing cells, activation of the UPS might ameliorate protein turnover already at low damage levels before massive protein misfolding ensues in a toxic environment.
Malina, J., Hannon, M. J. & Brabec, V. Recognition of DNA three-way junctions by metallosupramolecular cylinders: gel electrophoresis studies.
Zinc-finger proteins offer a versatile and effective framework for the recognition of DNA binding sites.
This modular design offers a large number of combinatorial possibilities for the specific recognition of DNA.
Understanding their molecular recognition of DNA is an important prerequisite to generate engineered enzymes able to cleave DNA in specific desired genome sites.
DNA inaccessibility is thought to restrict recognition of DNA templates by regulatory proteins and thus to hinder transcription while accessible chromatin structures may facilitate transcription15,26.
Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu JK et al. Structural basis for sequence-specific recognition of DNA by TAL effectors.
The authors suggest a mechanistic model whereby Rad26 ensures transcription-coupled recognition of DNA lesions while also functioning as a transcription elongation factor.
Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu J-K, et al. Structural basis for sequence-specific recognition of DNA by TAL effectors.
