Given the presence of T cells and the physical breakdown of the blood brain barrier from the cell injection itself, it was possible that allo antigen recognition was sufficient to prime a systemic immune response and that later analysis of mixed lymphocyte reactions would reveal the earlier exposure to allo antigens.
Conversely, multimerizing the Elba recognition sequence is sufficient to confer early insulating activity (Aoki et al., 2008; see Figure 1 figure supplement 1).
In particular, complementarity to the miRNA seed region, corresponding to nts 2 8 at the 5′ of the mature miRNA, is a major determinant in target recognition and is sufficient to trigger silencing (2).
If the requirement of explicit self recognition is a sufficient condition for the self-advantage, this should be found also in the Experiment 2. Alternatively, a dissociation between implicit and explicit self body processing should be found.
Potent antigen recognition is not sufficient for IgM-mediated HIV-1 inactivation.
The strength of foreign antigen recognition is considered sufficient to drive activation and the differentiation of naïve T cells into memory or effector T cells.
However, MHC-peptide recognition is not sufficient for full T cell activation, and a range of co-stimulatory ligand receptor interactions is also required that can provide either positive or negative signals.
We show that Neh2 domain is sufficient for recognition, ubiquitination, and proteasomal degradation of Neh2-luciferase fusion protein.
In addition, it has been reported previously that the MHC class I expression on mouse ESCs is sufficient for recognition by the SIINFEKL-specific T cell hybridoma B3Z [ 27, 65].
The difference between the steric occlusion model and the preinitiation-complex interference model hinges on whether the restriction of access of a protein to its recognition sequence in silenced chromatin is sufficient to account for the 1000-fold repressiof of silenced chromatin.
